Get A Systems Biology Approach to Study Metabolic Syndrome PDF

By Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)

ISBN-10: 3319010077

ISBN-13: 9783319010076

ISBN-10: 3319010085

ISBN-13: 9783319010083

The objective of this booklet is to supply the objective viewers, in particular scholars of medication, Biology, structures Biology and Bioinformatics, in addition to skilled researchers in learn fields suitable to metabolic syndrome (MetS) with an summary of the demanding situations and possibilities in platforms biology and the way it may be used to take on MetS. particularly, the goals are: (1) to supply an creation to the main organic procedures focused on the pathophysiology of MetS; (2) by utilizing particular examples, supply an creation to the most recent applied sciences that use a platforms biology method of learn MetS; and (3) to offer an summary of the mathematical modeling methods for learning MetS.

The essentially written chapters via best specialists within the box offers distinct descriptions an important for the original place of this booklet and its specialize in the appliance of platforms biology to take on particular pathophysiologically appropriate elements of MetS and gives a invaluable useful advisor to this study community.

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Extra resources for A Systems Biology Approach to Study Metabolic Syndrome

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By knock-down), which following the experiment leads to the conclusion that indeed function of Z depends on X (Fig. 1b). However, such an approach disregards potential other networks that may regulate Z as well as modulate the function of X (Fig. 1c). The so-obtained ‘mechanistic models’ therefore primarily describe the binary dependencies of molecular components and their functions. , the ‘other networks’ cannot be controlled for, it is thus not surprising that reproducibility of conclusions from molecular biology experiments is strikingly poor (Begley and Ellis 2012).

Symp Soc Exp Biol 27:65–104 Kell DB (2006) Metabolomics, modelling and machine learning in systems biology—towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and 9th IUBMB conference in Budapest. FEBS J 273:873–894 Korte SM, Koolhaas JM, Wingfield JC, Mcewen BS (2005) The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. –Or, what I learned while studying apoptosis. Cancer Cell 2:179–182 Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää A-L, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešiˇc M (2011) Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

Hepatic VLDL packages involve the fusion of an ApoB-100 molecule with lipid droplets of TG through the action of the microsomal transfer protein (MTP) within hepatocytes, preventing TGs accumulation (Fabbrini et al. 2010). The lipid excess is oxidized or released as VLDL. However, the hepatic ability to oxidized fat is limited; an increase in intrahepatic fat content leads to an up-regulation of oxidative mechanisms which are less efficient due to mitochondrial uncoupling (Gastaldelli et al. 2007; Sanyal et al.

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A Systems Biology Approach to Study Metabolic Syndrome by Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)

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