New PDF release: Adaptation to Altitude-Hypoxia in Vertebrates

By Prof. Pierre Bouverot (auth.)

ISBN-10: 3642823165

ISBN-13: 9783642823169

ISBN-10: 3642823181

ISBN-13: 9783642823183

Adaptation to altitude hypoxia is characterised by means of a spread offunctional adjustments which jointly facilitate oxygen trans­ port from the ambient medium to the cells of the physique. All of those alterations should be obvious at one time or one other during hypoxic publicity. but, as already under pressure (Hannon and Vogel, 1977), an exam of the literature provides just a sketchy and sometimes conflicting photograph of the precise nature of those alterations and the way they have interaction as a functionality of publicity period. this can be in part a result of constrained variety of variables explored in a given research, however it is additionally brought on by variations in experimental layout, changes between species in susceptibility to hypoxia, nonstandardized experimental stipulations, loss of right keep an eye on of actual (e. g. , temperature) and physiological variables (e. g. , physique mass), failure to take measurements at key sessions of publicity, and gaps in wisdom approximately a few basic mechanisms. in addition the on hand info on animals local to excessive altitude are meager and/or inconclusive. wide extra paintings less than well-controlled experimental stipulations is needed prior to an in depth photograph may be made. however, it's been a tenet within the prepara­ tion of this monograph really to summarize the tremendously dis­ persed fabric that constitutes the comparative body structure of variation to excessive altitude right into a coherent photograph, than to supply a finished survey of the field.

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Extra resources for Adaptation to Altitude-Hypoxia in Vertebrates

Example text

6 ! 1 body mass. DC ambient T . normox ic PIo,. Torr hypoxic PI o,. Torr Mo, . mmol/min .. ~O ...... 30 T,sec Fig. 2. Mean changes in the breathing pattern from normoxia to acute hypoxia in unanesthetized rat and pigeon (personal unpublished data) and carp (Itazawa and Takeda 1978). Ordinate tidal volume (VT); abscissa ventilatory period (T); oblique lines isoventilation lines (V). 8 ml, a value close to the dead-space volume for rat; this line represents the various VT- T combinations yielding constant effective ventilation (Veff) (see Sect.

Despite this tachypneic hyperventilation in chemodenervated animals, alveolar P02 will not return toward higher values, since the effective ventilation remains steady; similarly, alveolar PC02 will be unaffected, whereas it does decrease in intact animals, as considered next. 3 Associated Hypocapnia and Alkalosis An effective increase in the specific ventilation means an equally increased ventilatory conductance for CO 2 , The consequence is that the CO 2 partial pressure (and concentration) diminishes in the arterial blood and expired medium.

1982) may also provide an important influence in determining the breathing pattern of aerial vertebrates during hypoxia. A tachypneic response to hypoxia may have no adaptive value; for example, that exhibited by those mammals and birds experimentally deprived of arterial chemoreceptors (Davenport et al. 1947; Miller and Tenney 1975; Bouverot and Sebert 1979). This is schematically illustrated for rats by the dotted line in Fig. 8 ml, a value close to Vo, the expected dead-space volume (Stahl 1967); therefore, the general equation of the line is VT = Vo + aT, where a is the slope.

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Adaptation to Altitude-Hypoxia in Vertebrates by Prof. Pierre Bouverot (auth.)


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