By Robert B. McComb
There will be doubtless that alkaline phosphatase is among the so much greatly in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the convenience and sensitivity with which its job will be measured. regrettably, those wide-ranging yet usually superficial experimental stories were up through in depth and systematic investigations in just a couple of restricted components of the biochemistry and chemical pathology of alkaline phosphatase. the outcome has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already recognized proof concerning the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technology. " however, moments arrive in all spheres of medical job whilst generalization turns into crucial, to codify and to choose from the mass of knowledge already collected, and to supply beginning issues for brand spanking new advancements and new traces of research. this can be very true in a box akin to alkaline phosphatase learn, during which very actual hazards exist that the seeds of basic figuring out can be misplaced amidst an unexamined harvest of empirical observations. The background of the examine of alkaline phosphatase offers numerous situations whilst worthy generalizations have emerged. sometimes, the conclusions drawn at the foundation of accessible facts have been unsuitable; extra usually, they've got stood the attempt of additional experimentation, and constantly, they've got supplied new insights into the character and correct ties of this enzyme.
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Discoideum life cycle. Activity is highest in the tip of the young fruiting body and lowest in the spore mass. 3S ,36 High activities are also found at the tip of the developing stalk in such species as D. mucoroides and D. purpureum. 35 High concentrations of orthophosphate in the growth medium repress the synthesis of the enzyme. 38 Cycloheximide, an inhibitor of protein synthesis, suppresses the rise in alkaline phosphatase activity during sorocarp formation in D. discoideium. 39 Actinomycin D, an inhibitor of RNA synthesis, can also prevent this rise, provided it is added early during development.
The status of phosphorus in certain food materials and animal by-products, with special reference to the presence of inorganic forms, Am. Chern. , 30, 470, 1903. 17. , Uber enzymatische Zersetzung der Nucleinsaure, Z. Physiol. , 38, 84, 1903. 18. , Uber ein Enzym "Phytase" das "Anhydro-oxymethylen-diphosphorsaure" spaltet, Bull. Call. Agric. Tokyo Imp. , 7,503,1907. 19. Suzuki, Umetaro (1872-1943), in: Japan Biographical Encyclopedia, 1st ed. ), Rengo Press, Tokyo, 1958. 20. McCollum, E. , and Hart, E.
Bioi. , 86, 671,1930. 115. , Phosphatase studies. I. Determination of inorganic phosphate; Beer's law and interfering substances in the Kuttner-Lichtenstein method, J. BioI. , 99,197,1932. 116. , Phosphatase studies. II. Determination of serum phosphatase: Factors influencing the accuracy of the determination, 1. BioI. , 101, 93, 1933. 117. , liber die fermentative Spaltung der verschiedenen Phosphosaureester, J. Biochern. (Tokyo), 11, 143, 1929. 118. Bessey, O. , Lowry, O. , and Brock, M. , A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum, J.
Alkaline Phosphatase by Robert B. McComb