By Koichiro Niwa, Harald Kaemmerer
This is the 1st textbook to target Aortopathy, a brand new medical thought for a kind of vasculopathy. the 1st portion of the ebook starts off from discussing basic idea and historical past of Aortopathy, after which bargains with its pathophysiology, manifestation, intrinsic issue, medical implication, administration and prevention. the second one half heavily appears at numerous issues of the Aortopathy corresponding to bicuspid aortic valve and coarctation of aorta. The ebook editors have released loads of works at the subject and feature been accumulating bearing on facts within the box of congenital center sickness for the prior twenty years, hence current the publication with confidence.
The subject - an organization of aortic pathophysiological abnormality, aortic dilation and aorto-left ventricular interplay - is getting an increasing number of recognition between cardiovascular physicians. this is often the 1st ebook to refer for cardiologists, pediatric cardiologists, surgeons, ACHD experts, and so on. to procure thorough wisdom on Aortopathy.
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These aneurysmal pulmonary trunks had severe medial abnormalities (Fig. 8) attributed to abnormal flow patterns originating in utero. Absent pulmonary valve is often accompanied by pulmonary artery aneurysm and occasionally reveals cystic medial necrosis in the pulmonary trunk [57, 58]. 9 K. Niwa Neural Crest Cell and Elastic Fiber Deficit in Great Arteries in Congenital Heart Disease Maldevelopment of neural crest cells could be responsible for the occurrence of conotruncal anomalies (truncus arteriosus, d-transposition of the great arteries, tetralogy of Fallot with pulmonary atresia), ventricular outflow tract anomalies (bicuspid aortic valve, absent pulmonary valve), and aortic arch anomalies (coarctation of the aorta, interruption of the aorta, double aortic arch) [30, 59].
1 Introduction From the physiological view, the aorta has two functions: conduit function and reservoir function. The conduit function is easy to understand. A typical disorder with the failure of the conduit function is aortic coarctation (Fig. 1) . The disease brings about left ventricular hypertrophy and afterload mismatch. However, the reservoir function and the problem of it are not well known. In this section, the reservoir function of the aorta will be explained. T. D. jp © Springer Japan KK 2017 K.
Murakami T, Takei K, Ueno M et al (2008) Aortic reservoir function after arterial switch operation in elementary school-aged children. Circ J 72:1291–1295 13. Murakami T, Niwa K (2015) Aortic stiffening and dilation: influence on coronary supplydemand balance. J Am Coll Cardiol 65:2262 14. Murakami T, Shiina Y, Niwa K (2016) Letter by Murakami et al regarding article, “segmental aortic stiffening in children and young adults with connective tissue disorders”. Circulation 133:e9 15. Nichols WW, O’Rourke MF, Vlachopoulos C (2011) McDonald’s blood flow in arteries, 6th edn.
Aortopathy by Koichiro Niwa, Harald Kaemmerer