Read e-book online Arrhythmogenic right ventricular cardiomyopathy dysplasia: PDF

By Frank I. Marcus, Andrea Nava, Gaetano Thiene

ISBN-10: 8847004896

ISBN-13: 9788847004894

ISBN-10: 884700490X

ISBN-13: 9788847004900

This booklet covers all points (biological, pathological, genetics, scientific and therapeutical) of arrhythmogenic correct ventricular cardiomyopathy/dysplasia, a up to date cardiomyopathy which represents a really excessive chance of unexpected dying within the younger and in athletes. The monograph provides the result of 5-year study software on ARVC/D supported by way of gives you of either the ecu fee and the NIH, which enabled the invention of seven disease-causing genes, therefore beginning new avenues for the early id of affected sufferers and for surprising loss of life prevention. A panel of most sensible scientists, either eu and americans, contributed to this quantity, to be able to be an important reference for execs and citizens in cardiology, radiology, human genetics, and game medication.

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Sudden death or aborted sudden 25 death almost always occurred in subjects without a previous diagnosis and rarely in already diagnosed patients; congestive heart failure was quite rare. The degree of arrhythmic risk is difficult to quantify; however, our data confirmed previous observations regarding its relation to the extent of the disease, presence of complex ventricular arrhythmias and episodes of the “acute phase” of the disease, that in many cases were not predictable. Moreover, evaluation of families carrying DSP and PKP2 mutations showed that ECG/SAECG and 2D-echo finding were normal in a significant percentage of mutation carriers [7, 22].

Beffagna et al. [6] found a proband in one family with mutations of this gene. Clinical analysis of 12 TGFbeta 3 mutation carriers lead to a diagnosis of ARVC/D in nine subjects (75%). The 12-lead ECG, SAECG, and 2D-echo findings were similar to those reported in DSP and DSG2 carriers. TGFbeta 3 is a member of the transforming growth factor family, a large group of regulatory cytokines that has a pivotal role in tissue development and homeostasis [24]. TGFbeta 3 induces a fibrotic response in various tissues in vivo [25] by promoting expression of extracellular matrix genes and by suppressing the activity of genes such as matrix metalloproteinases, which are involved in extracellular matrix degradation [26, 27].

Published a genotype-phenotype correlation study of nine families carrying PKP2 mutations [22]. Among the 34 subjects with a PKP2 mutation, 32 had clinical evaluation and 17 (53%) were found to fulfil the ARVC/D diagnostic criteria. An additional nine presented some cardiac signs of the disease. Right ventricular structural abnormalities were present in 20 (62%), mutations carriers and abnormal ECG/SAECG features in 21 (66%). Antoniades et al. studied 22 PKP2 carriers and 26 homozygous JUP carriers and found a similar cardiac phenotype [23].

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Arrhythmogenic right ventricular cardiomyopathy dysplasia: Recent Advances by Frank I. Marcus, Andrea Nava, Gaetano Thiene


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