By Vladimir M. Mirsky, Anatoly Yatsimirsky
The 1st to supply systematically geared up details on all 3 vital points of synthetic receptor layout, this ebook brings jointly wisdom on a very scorching and multidisciplinary box of analysis. powerful emphasis is put on the method for locating man made receptors, with either definitions for chemosensitivity in addition to experimental setups provided. There follows assurance of various sessions of man-made receptors, together with synthesis, immobilization on surfaces, and quantitative information on houses. The 3rd a part of the e-book specializes in receptor arrays for synthetic nostril and tongue functions and the complete is rounded off with an outlook and an appendix with all suitable quantitative facts on man made receptors.
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Extra info for Artificial Receptors for Chemical Sensors
10 shows logarithms of stepwise binding constants of trianions 6a–c with protonated forms of both macrocycles as a function of degree of protonation. Plots are roughly linear with positive slopes in agreement with primarily electrostatic nature of complex formation, but for a given degree of protonation of the macrocycle the binding constants for different isomers are signiﬁcantly different despite the similar charge of all guest anions. Binding of symmetrical trianion 6c is stronger than that of other guests with both macrocycles.
KGaA, Weinheim ISBN: 978-3-527-32357-9 j 2 Selectivity of Chemical Receptors 18 with coordination complexes, an optimal afﬁnity is reached if bonds between transition metal ions and the donor functions are formed with a minimum of strain energy [4, 5]. Strain may originate from the formation of bonds between receptor and analyte, as well as from deformation of the analyte or receptor molecule by an induced ﬁt. Another limitation is that, due to solvation and likely entropic factors, a higher binding constant is often observed if the guest molecule enjoys more freedom, and occupies only part of the space inside a host cavity .
J41 j 2 Selectivity of Chemical Receptors 42 Placement of several metal centers at distances designed, for example, with the help of computer-aided molecular modeling allows by geometric matching distinction of, for example, peptides and even proteins containing, for example, lysine or histidine. Obviously, an optimal match will lead to optimal strength and selectivity, in particular if the interactions are not soft, as in the case of ion pairing or coulombic forces, but fall off signiﬁcantly with non-ideal distances between interacting sites.
Artificial Receptors for Chemical Sensors by Vladimir M. Mirsky, Anatoly Yatsimirsky