By R. Zwilling (auth.), Professor Dr. Robert Zwilling, Professor Dr. Cesare Balduini (eds.)
bhe goal of the booklet used to be to not concentration the age-dependent transformations of 1 particular organic platforms or phenomena, however the try was once pursued to hide a number of fields within which the organic learn on getting older is occurring. the elemental function of this making plans used to be to provide the PhD scholars a sophisticated textual content which could increase the potential for an interdisciplinary dialogue on a large and intricate box that's very compatible to be applied to illustrate of the relationship latest among complicated educating and experimental research.
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Oxidative state of membrane proteins during red cell life span was quantitated by measuring methionine sulfoxide (MetSO)  and thiol group content  of ghost membranes obtained from erythrocytes of different ages, density separated by centrifugation in autologous plasma [53 - 55] and characterized for their creatine content as a cell-age parameter [56, 57]. Oxidative state of individual membrane proteins was determined in intact cells by measuring the amount of the thiol-reagent N-(7-dimethylamino-4-methylcoumarinyl)-maleimide (DACM) bound in situ by each membrane protein [58) 32 A.
Mech Ageing Dev 16: 205-219 32. Kempka G, Kolb-Bachofen V (1981) Galactose-specific receptors on liver cells. Hepatocyte and liver macrophage receptors differ in their membrane anchorage. Biochim Biophys Acta 847: 108 - 114 33. Westerman MP, Pierce LE, Jensen WN (1963) Erythrocyte lipids: a comparison of normal young and normal old populations. J Lab Clin Med 62: 394 - 400 34. Winterbourn CC, Batt RD (1970) Lipid composition of human red cells of different ages. Biochim Biophys Acta 202: 1 - 8 35.
2). This was better shown by the assay of MetSO residues than by thiol titration, when studies were carried out on ghost membranes. MetSO assay provided evidence of a significant increase in the oxidation of methionine from young to mature and senescent erythrocytes, whereas no significant difference appeared between mature and senescent cells (Fig. 2). The amount of MetSO in middle-aged erythrocytes is 500,10 higher than in membrane proteins of young cells, but it does not increase further. '~-SH 100 b~~~ ~ ~ 50 bend 4 1 bend 42 1/T-1--r--r-I/...
Biology of Aging by R. Zwilling (auth.), Professor Dr. Robert Zwilling, Professor Dr. Cesare Balduini (eds.)