New PDF release: Capillary Electrophoresis - Mass Spectrometry (CE-MS)

By Gerhardus de Jong

ISBN-10: 3527339248

ISBN-13: 9783527339242

ISBN-10: 3527693807

ISBN-13: 9783527693801

ISBN-10: 3527693815

ISBN-13: 9783527693818

ISBN-10: 3527693823

ISBN-13: 9783527693825

ISBN-10: 3527693831

ISBN-13: 9783527693832

This monograph deals the reader a whole evaluate on either ideas and functions of CE-MS. beginning with an introductory bankruptcy on detection in CE, additionally similar and extra really good recommendations resembling electrophoretic and chromatographic preconcentration are mentioned. a distinct emphasis is wear CE-MS interfaces, that are defined intimately. In a separate bankruptcy, recognition is paid to sheath-liquid interfacing. The advancements and chances of microchip CE-MS also are defined. purposes to all appropriate parts are mentioned in specified chapters, each one written via specialists within the respective fields.
along with purposes in pharmaceutical research and bioanalysis, fresh implementations in meals technological know-how, forensic research, research of intact proteins, metabolomics and proteomics are highlighted. MS is a wonderfully acceptable detection approach for CE, as effective separation is coupled to delicate and choice detection. additionally, MS delivers constitution info at the separated compounds. CE-MS has now been built right into a robust hyphenated procedure complementary to LC-MS. This monograph is an distinctive resource of information for everybody facing and drawn to CE-MS

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Additional info for Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications

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B) Total ion chromatogram for a protein mixture separated in an N–CHO coated capillary. Reproduced from Zhong et al. [38] with permission of American Chemical Society. 2 Glycan Analysis by CE-ESI-MS Protein glycosylation is an important posttranslational modification, enabling functions such as cell–cell signaling and interactions [75, 76]. The structural analysis and identification of glycans from glycoproteins can be achieved using mass spectrometry, but due to the number and complexity of glycans that can be obtained, separation before MS analysis is often necessary [75].

Microfluidics and lab-on-a-chip). CE, as a nanotechnique, is well suited toward miniaturization, and a CE-MS interface that can operate within nanoliter flow rate ranges is invaluable. As CE-ESI-MS interface development continues to show promise in the areas of reduced flow rate and increased sensitivity, the incorporation of microfluidic separation platforms prior to MS analysis becomes more and more practical. A trend toward micro total analysis systems is valuable for volume-limited samples and progressing -omics studies.

The CE-MS interface improves the ionization efficiency of the mobilized effluent without significant dilution. (b) Total ion chromatogram for a protein mixture separated in an N–CHO coated capillary. Reproduced from Zhong et al. [38] with permission of American Chemical Society. 2 Glycan Analysis by CE-ESI-MS Protein glycosylation is an important posttranslational modification, enabling functions such as cell–cell signaling and interactions [75, 76]. The structural analysis and identification of glycans from glycoproteins can be achieved using mass spectrometry, but due to the number and complexity of glycans that can be obtained, separation before MS analysis is often necessary [75].

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Capillary Electrophoresis - Mass Spectrometry (CE-MS) Principles and Applications by Gerhardus de Jong


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