Chemistry and Pharmacology of Anticancer Drugs by David E. Thurston PDF

By David E. Thurston

ISBN-10: 0849392195

ISBN-13: 9780849392191

ISBN-10: 1420008900

ISBN-13: 9781420008906

Whereas drug remedies built within the final 50 years have markedly more desirable the administration of a few forms of cancers, remedy results, and drug side-effects for the commonest varieties stay unacceptable.  in spite of the fact that, contemporary technological advances are resulting in stronger treatments in keeping with focusing on special organic pathways in melanoma cells. Chemistry and Pharmacology of Anticancer Drugs is a finished survey of all households of anticancer brokers presently in use or in complex levels of medical trials, together with biologicals.

The ebook is exclusive in supplying molecular constructions for all anticancer medicines, discussing them by way of heritage, chemistry, mechanism of motion, structure-function relationships, and pharmacology. It additionally offers a few correct info on unwanted effects, dosing, and formula. the writer, a popular scientist in melanoma study and drug improvement, additionally offers updated info at the drug discovery approach, together with new study instruments, tumor-targeting innovations, and primary innovations within the rising components of customized drugs (e.g., oncogenomics) and chemoprevention.

Chemistry and Pharmacology of Anticancer Drugsis an essential source for melanoma researchers, medicinal chemists, and different biomedical scientists keen on the advance of recent anticancer remedies. Its breadth of assurance additionally makes it compatible for undergraduate and postgraduate classes in medication, pharmacy, nursing, and similar disciplines.

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Extra resources for Chemistry and Pharmacology of Anticancer Drugs

Sample text

Intelligent Drug Design,” Nature, 384:1-26, 1996. H. “New Approaches to Antitumor Therapy,” Annu. Rep. Med. , 24:121-128, 1989. J. Molecular Biology of Cancer. Oxford: BIOS Scientific Publishers, 1997. , ed. The Cancer Handbook, vol. 1. London: Nature Publishing Group, 2002. B. The Anticancer Drugs. Oxford: Oxford University Press, 1994. B. The Organic Chemistry of Drug Design and Drug Action, Second Edition. London: Academic Press, 2004. , and Daniels, S. Practical Chemotherapy: A Multidisciplinary Guide.

However, double-strand breaks can also occur. These are more serious for the cell; they usually lead to cell death because they cannot be joined by ligases and are instead degraded by nucleases. Modifications to DNA bases that do not lead to strand cleavage can also occur. For example, oxidized bases can occur that block transcription and replication and are usually lethal for the cell. The DNA-damaging effects of X-rays (predominantly double-strand DNA breaks) are also put to good use in radiotherapy, in which an X-ray beam is focused on a tumor in order to kill cancer cells by fragmenting their DNA.

Gene Therapy of Solid Tumors,” Brit. Med. , 51:192-204, 1995. G. “Viruses and Cancer,” Brit. Med. , 47:21-46, 1994. A. “The Hallmarks of Cancer,” Cell, 100:57-70, 2000. L. “Drug Resistance,” Brit. Med. , 47:178-196, 1991. “Intelligent Drug Design,” Nature, 384:1-26, 1996. H. “New Approaches to Antitumor Therapy,” Annu. Rep. Med. , 24:121-128, 1989. J. Molecular Biology of Cancer. Oxford: BIOS Scientific Publishers, 1997. , ed. The Cancer Handbook, vol. 1. London: Nature Publishing Group, 2002.

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Chemistry and Pharmacology of Anticancer Drugs by David E. Thurston


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