's Ciba Foundation Symposium 146 - Photosensitizing Compounds: PDF

ISBN-10: 0470513845

ISBN-13: 9780470513842

ISBN-10: 0471923087

ISBN-13: 9780471923084

Convinced natural compounds can develop into poisonous to organic tissue whilst activated via gentle. Many clinical purposes of this influence were studied over the last two decades, and This symposium brings jointly chemists, biologists, and clinicians to debate the elemental chemistry of the sensitizing compounds, their organic results, and scientific functions in remedies of varied cancers and dermis problems.

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This provides essentially the total storable energy input into the biosphere, and depends mainly on two magnesium (11) dihydroporphyrins, chlorophylls a and b. Photosynthesis is an evolved photobiological process which operates on a very short time-scale with few side-reactions because the components of the photoreaction centre have a precise and purposeful relationship to one another (Deisenhofer & Michel 1987). As illustrated in Fig. 1, the processes involved in tumour phototherapy are quite different.

One must take into account the sensitivity t o the environment of the rate constant for the reaction of singlet oxygen with tryptophan. For example, this rate constant is five times lower in methanol than in aqueous solution. A pure singlet oxygen mechanism is followed in both media, but if one were to compare the rates at which tryptophan disappears one might believe that in methanol the singlet oxygen generation is much less efficient, which is not true; the quantum yield of singlet oxygen generation is the same, or perhaps higher, in methanol compared with in water.

Truscott: Most people would say that is diagnostic. There are examples, which I don’t understand, of a D 2 0 effect on the triplet yield. That throws some doubt on such an assay, but normally there is a 10-fold increase in singlet oxygenmediated tryptophan oxidation in D20. Moan: What about the triplet lifetimes of these porphyrins and phthalocyanines in D 2 0 rather than H 2 0 ? Truscott: I have not measured that. Jori: This is limited to aqueous media, not mixed solvents. It would be Phthalocyanine photosensitizers 31 interesting to study the effect of D 2 0 on the type I mechanism.

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Ciba Foundation Symposium 146 - Photosensitizing Compounds: Their Chemistry, Biology and Clinical Use


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