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These activities are responsibilities as described in the preanalytical and postanalytical processes of the total testing process as defined by CLIA ’88. Therefore, it is important that students learn the diagnostic process in order to assume this type of role, which will improve patient safety outcomes—a quality indicator. Another method of regulating quality in the health-care industry is through occupational licensure laws. Unfortunately, the clinical laboratory industry is not uniform in this regard.
1–9). Carbohydrate molecules can be used to produce proteins; the carbon skeleton of amino acids can be converted to certain carbohydrates. Lipid structures such as glycerol may be Carbohydrate Metabolism Proteins Nucleic acids Polysaccharides Bases Amino Acids Lipids Triacylglycerols Isoprenoids 1 Glucose Pentoses Fatty acids Glycerol 3 2 ATP NADHP NADH Other biosynthetic reactions Pyruvate 4 5 NADH FADH2 Acetyl-CoA NADH NH3 1. Pentose phosphate pathway 2. Gluconeogenesis 3. Glycolysis 4. beta-oxidation 5.
Bile is composed of water, salts, pigments, and fatty acids that have been processed by the liver. Bile emulsifies fats into small particles to make them more digestible by intestinal enzymes. The liver regulates most chemical levels in the blood and excretes bile, which remove waste products from the body. The many function of the liver include • production of bile, which helps remove waste (especially fat-soluble waste) through the digestive tract • production of plasma proteins • production of endogenous cholesterol • production and storage of glycogen for storage glucose units • breakdown of amino acids and conversion of the toxic breakdown product, ammonia, to urea • conjugation of bilirubin • biotransformation of xenobiotics, including drugs These substances serve as biochemical markers of liver disease.
Clinical Chemistry A Laboratory Perspective by F.A.Davis