By Michael Alan Singer
This publication describes a unique and special approach to the remedy of human illnesses in accordance with the learn of typical animal versions. A ordinary animal version is outlined as an animal workforce or species that possesses a collection of biochemical/physiological features that are common and adaptive for that animal, yet are really irregular for people. for instance, how is it that birds can tolerate blood glucose concentrations which in people are linked to diabetes. The common animal version resides evidence organic resolution to this question is offered. by means of learning common animal versions, we will be able to achieve worthwhile insights into the therapy of varied human medical problems. protecting quite a lot of issues, this ebook describes intimately how scientific scientists can reap the benefits of the entire "research" that nature has already played over billions of years in organic challenge fixing via huge animal layout trying out and choice.
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Extra info for Comparative Physiology, Natural Animal Models and Clinical Medicine: Insights into Clinical Medicine from Animal Adaptations
The signiﬁcance of this autocrine circuit is unclear. , 1995; Yang and Cepko, 1996). Astrocytes expressing VEGF spread across the innermost axon layer at approximately the same time as a superﬁcial layer of vessels form and extend across the surface of the retina. Somewhat later a deeper layer of vessels also form and this process is associated with VEGF expression by Muller cells. Stone et al. (1995) also demonstrated that the VEGF receptor Flk1 is expressed by endothelial cells in the forming vessels.
1997b. Expression of the Na+ /glucose co-transporter (SGLT1) along the length of the avian intestine. Biochem. Soc. Trans. 25, 480S. , 2002. Expression of monosaccharide transporters in intestine of diabetic humans. Am. J. Physiol. Gastrointest. Liver Physiol. 282, G241–G248. , 1993. Cloning and analysis of the gene encoding hummingbird proinsulin. Gen. Comp. Endocrinol. 91, 25–30. , 1991. Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.
Interestingly, Barfull et al. (2002) found that the density of the sodiumglucose co-transporter SGLT1 in chicken jejunum brush border membrane was 40% less in the adult than in the two-day-old chicken. This decrease was not the result of a change in diet or intraluminal glucose concentration. , 1997a). , 1991). Therefore for chicken enterocytes, transcellular glucose ﬂux would be less in the adult than in the newborn. This ﬁnding is similar to the situation in avian erythrocytes although erythrocytes lose transporters during maturation whereas enterocytes lose transporters later after hatching.
Comparative Physiology, Natural Animal Models and Clinical Medicine: Insights into Clinical Medicine from Animal Adaptations by Michael Alan Singer